Mechanotransduction at the Nuclear Envelope
نویسندگان
چکیده
منابع مشابه
Dynein at the nuclear envelope.
Most cellular organelles are posi tioned through active transport by motor proteins. this is espe cially important during cell division, a time when the organelles and genetic content need to be divided equally between the two daughter cells. although individual proteins can attain their correct location by diffusion, larger structures are usually posi tioned through active transport by moto...
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This article is part of a Minifocus on exploring the nucleus. For further reading, please see related articles: ‘Integrating one-dimensional and threedimensional maps of genomes’ by Natalia Naumova and Job Dekker (J. Cell Sci. 123, 1979-1988) and ‘Connecting the transcription site to the nuclear pore: a multi-tether process regulationg gene expression’ by Guennaëlle Dieppois and Françoise Stutz...
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The nuclear envelope (NE) is a unique topological structure formed by lipid membranes (Inner and Outer Membrane: IM and OM) interrupted by open channels (Nuclear Pore complexes). Besides its well-established structural role in providing a physical separation between the genome and the cytoplasm and regulating the exchanges between the two cellular compartments, it has become quite evident in re...
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Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements. The complexes are built from members of two evolutionary conserv...
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The findings of two recent studies suggest a novel mechanism for nuclear envelope breakdown in which cytoplasmic dynein anchored on the outside of the nucleus generates tension, thus triggering tearing of the nuclear envelope.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2453